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Neil and Munjas2 conducted a phenomeno- logical study of 10 patients with chronic non- healing wounds, in which two patterns and six themes emerged.
These treatments can heal wounds, but patients must comply with the treatment plan because biofilms can re-form within a day and the wound will not heal.
The molecular and cellular environment of chronic wounds differs substantially from that of acute healing wounds.
Specifically, non- healing wounds have chronically elevated pro-inflammatory cytokines, which lead to chronically elevated levels of proteases (MMPs and neutrophil elastase) and reactive oxygen species (ROS) that degrade the components that are essential to healing, such as ECM components, growth factors, and receptors.
"The Effect of Antiseptics on the Healing Wound: A Study Using the Ear Chamber," British Journal of Surgery 72(10):780-82, October 1985.
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